In Queensland, the formation of the Queensland One Health Group (QOHG), including veterinarians, environmental officers, industry representatives and medical staff, has enhanced communication between disciplines and improved understanding between the specialties with the aim of early recognition of threats to health. Although One Health is not a new concept, it is not often considered in medical practice. Six interlinked cases of canine and human Brucella suis infection highlight the use of One Health principles in medical practice. Other examples of One Health in practice include the impact of the 2011 Queensland floods on health, recognition of the importance of vector distributions in Queensland and consideration of the environment in the transmission of multi-resistant organisms